OK, before we elucidate as to the safest procedure, there are two items you should never remove from ZorinOS or other forks of Ubuntu.
1. Never remove Nautilus - this is the Desktop Explorer application - it will break your installation.
2. Similarly, PulseAudio - removing this will also break your installation.
3. Rhythmbox - removing this will also break your installation.
4. Evolution - I have not tried to remove this in Zorin 15 but in earlier versions, elements of Evolution were present because Ubuntu was built around or rather had the Evolution Calendar element present in order for the time and date to be shown correctly within the system - if you removed any element of Evolution whilst the main package itself was not installed, would also lead to a broken system.
Now the safest way to remove a package is via Synaptic Package Manager. This is not installed by default in either Zorin 12 or 15 but is available in the Software 'channel'. Once installed, use the search function for the application/packages you want to remove. Do this one at a time and when you 'mark for removal', you should get a window that opens that indicates a heading, 'To be removed' - expand it to see what packages are going to be removed - if you see anything that is likely to remove a system application as the ones listed in the 'never remove' list above then cancel the removal. It is without doubt one of the negatives of Ubuntu and other distributions that too many applications are becoming 'embedded' with the OS and thereby restricting the GNU/Linux users' 'freedom of choice'.